The Prosser Lab
Benjamin Prosser, PhD; Ingo Helbig, MD; and Beverly Davidson, PhD
University of Pennsylvania
“Targeting micro-RNAs to treat genetic epilepsies”
Supported by AES, The Cute Syndrome Foundation, and SLC6A1 Connect
Scientist Thesis Statement: Numerous genetic epilepsies arise from haploinsufficiency, the reduced expression of epilepsy associated genes. The Prosser lab hypothesizse that the expression of downregulated genes can be restored through antisense oligonucleotides (ASO) that specifically disrupt gene repression by microRNAs (miRs).